GCMS-QP2010 Ultra/GCMS-QP2010 SE

                                                                                                                                                            Ultra spec - short form

Model                     　GCMS-QP2010 Ultra/SE

Manufacturer        　Shimadzu Corporation

 

[Product Concept]

GCMS-QP2010 Ultra/SE is our most advanced gas chromatograph mass spectrometer, upgraded in performance and usability from the GCMS-QP2010 Plus and GCMS-QP2010 S respectively.  A newly designed electronic control protocol allows for best–in-class scanning speed. This improved data collection speed makes this the perfect instrument for Fast GC or comprehensive GCMS (GCxGCMSq) analyses. Lab productivity and sample throughput are automatically increased. Ecology mode saves power and carrier gas consumption allowing for a lower cost of ownership and less environmental stress.

 

[Hardware Specifications]

GC Oven

Equipped with a double-jet cooling system, the system enables the reduction of cool down time　from 450 ℃ to 50 ℃ in 3.4 minutes.

 

GC Interface

The GC interface is short and offers excellent temperature uniformity. This minimizes any influence on chromatogram peaks and allows analyzing compounds with high boiling points.

·    Length                      Approx. 15cm

·    Temp. range              50 to 350 ℃

·    Column                     Direct connection up to i.d. 0.53mm is available. Metal capillary column is available.

 

Injection maintenance

The Easy sTop navigator assists in taking the appropriate steps. With the GCMS-QP2010 Ultra, safe and easy maintenance like replacement of injection insert and septum is possible without venting the MS so downtime is minimized.

 

Ion source

Front-opening chamber makes it easier for maintenance of the ion source. The ion source box can be disassembled easily without filament and lens dismounted.

·    Ionization mode     Ultra:    EI (Standard) , PCI (Optional*) and EI/PCI/NCI (Optional*)

SE:           EI (Standard)

(*) PCI mode is available with PCI model or PCI/NCI model.

     NCI mode is available with PCI/NCI model.

     Remained CI ion box equipped, the PCI/NCI model is capable of measuring EI and CI (SEI and SCI mode).

·    Electron energy            10 to 200eV

·    Emission current           5 to 250µA

                                          Three modes (high-concentration mode, standard mode, high-sensitivity mode*) are switchable in tuning.

(*) High-sensitivity mode is available only to Ultra model.

·    Filament                 Dual rhenium coil type (automatic change-over)

·    Temperature                      Ultra: 140 to 300 ℃

SE: 140 to 260 ℃

·    Maintenance                      Operation guided by MSNAVIGATOR

 

Analyzer

Highly accurate quadrupole rod enables high-sensitivity analysis in a wide mass range. Analyzer in high differential vacuum system can deliver superior ion transmission.

·        Mass analyzer                       Metal quadrupole mass filter with pre-rod

·        Contamination prevention      Vacuum: Differentially pumped vacuum system

                                                   Quadrupole: With pre-rods

·        Mass range                           Ultra:    m/z 1.5 to 1090  (scanning at 0.1u step)

　　　　　　　　　　　　         SE:       m/z 1.5 to 1000  (scanning at 0.1u step)

·        Resolution                             R > 2M (FWHM)

·        Stability                                  +/- 0.1u/48hours (Constant temperature)

 

Detector

The installation of overdrive lens has reduced the random noise that occurs with ion transmission, improving the S/N ratio. The secondary electron emission surface on the detector features a special surface treatment which provides a long service life. This ensures stable performance even when exposed to atmospheric conditions.

·        Detector unit                 Secondary electron multiplier with the patented overdrive lens and 10 kv conversion dynode

·        Detector                       ACTIVE FILM Multiplier®

·        Dynamic range              8 x 10⁶ (Maximum dynamic range of overall electrical circuit)

 

Vacuum system

A high-capacity dual-inlet turbomolecular pump and a differential vacuum system that evacuates the ion source and mass analyzer independently allow the column flowrate to be set to a maximum of 15 mL/min. Furthermore, the vacuum system is fully automated to make ON/OFF of each pump in start-up and shut-down, or opening and closing of leak valve. Also vacuum evacuation will be automatically shut off when being abnormal in vacuum status.

·        Vacuum evacuation            Ultra:    Differentially pumped system

SE:           Single pumping system

·        Turbomolecular pump        Ultra:    200/200 dual-Inlet differential vacuum system

(179/185L/sec for He)

                                   SE:      Single pumping system (58L/sec for He)

·        Fore-pump:                       30L/min (60Hz) Rotary pump

·        Vacuum control      Fully Automatic

Execution of automatic opening and closing of AFC, turbo pump, fore-pump and leak valve by automatic start-up and shut-down

·        Vacuum gauge       Ultra:    Ion gauge and pirani gauge (Standard)

SE:           Pirani gauge (Standard)

·        Column flow                      Ultra:    Up to 15mL/min (EI), 5mL/min (PCI, NCI)

SE:           Up to 4mL/min

·        Column connection            Direct connection up to i.d. 0.53mm is available.
                  

Scan speed

Scan speed is automatically set to the optimal value, based on the scan interval and measurement mass range. Settings can be set in extremely small steps. The Ultra has 201 steps between the minimum and maximum scan speed settings and the SE has 200 steps. The ASSP (Advanced Scanning Speed Protocol) function minimizes any drop in sensitivity at scan speeds above 10,000 u/sec.

·        Maximum scan speed        Ultra:    20,000u/sec

SE:           10,000u/sec

·        Maximum repeat rate         Ultra:    m/z 50～950 (900u) at 0.06 sec interval at 0.1u step

SE:           m/z 50～950 (900u) at 0.1 sec interval at 0.1u step

·        Minimum measurement interval

10msec（Maximum 100scan/sec）

 

SIM (Selected Ion Monitoring)

SIM integral time is optimized based on measurement interval and number of monitored ions. Scan measurement can be set up as ion set group (time program) and scan and SIM measurement mode can be switched during analysis.

·        Maximum monitored ion     64 channels

·        Maximum ion set                128 Ion sets

·        Minimum interval                10msec (Max. 4 ions at 10 ms)

 

FASST (Fast Automated Scan/SIM Type)

FAAST (Fast Automated Scan/SIM Type) is a data acquisition technique that allows the user to collect Scan data which provides a great deal of qualitative information and SIM data which provides much greater sensitivity than scan seemingly and simultaneously in a single analysis. With the FAAST technique, a scan chromatogram and SIM chromatogram can both be obtained by switching at high speed between Scan and SIM modes for data acquisition. FAAST measurement conditions are created automatically from method file for scan analysis by using COAST（Creation of Automatic SIM/FASST Table）which is a wizard that allows the user to quickly set up a Scan/SIM data acquisition method. Easy fine-tuning is also possible by referring chromatogram.

 

Ecology mode (ECO mode)

Equipped with Ecology mode, power and carrier gas consumed in analysis standby mode are reduced. Ecology mode can be entered automatically after continuous analysis and so power and carrier gas can be saved automatically.

 

Sensitivity

Specifications for installation check are as follows:

(Column: 30m×0.25mm×0.25µm Rtx-5ms column）

 

EI         Scan mode      Ultra: 1pg　 S/N > 500 Octafluoronaphthalene m/z 272.0

                       SE:  1pg　 S/N > 200 Octafluoronaphthalene m/z 272.0

Scan range 200 - 300      0.2s interval

 

PCI      Scan mode      Ultra:   100pg  S/N > 500 Benzophenone      m/z 183.1

PCI gas:  CH₄         Scan range 100 - 2500.6s interval

 

NCI      Scan mode      Ultra:   100fg   S/N ≧500 Octafluoronaphthalene  m/z272.0

NCI gas:  CH₄     Scan range 200 - 300             0.2 interval

 

PCI/NCI （PCI model and PCI/NCI model）

Reagent gas    Methane, isobutene, ammonia

Gas introduction          2 lines (Two types of the reagent gas above can be connected.)

Tuning            Auto-tuning is possible.

Ion source       Ion source box (Exchange type)

EI and PCI spectrum can be obtained by using NCI source (PCI/NCI Model)

 

DI（Optional）

Temp. setting               to 500 ℃

Temp. rising speed            5, 10, 20, 40 and 80 ℃/min.

Maximum (Temperature rising at maximum output)

Temp. program                        Programmed temperature rising up to 5 levels

Vial size                                   I.D. approx. 1.9mm,  Depth approx. 8mm

 

[Software Specifications]

The new workstation software for GCMS-QP2010 Ultra/SE systems, GCMSsolution version 2.6, is a fully 32-bit application with an assistant bar that shows operating procedures graphically and a wizard function that helps enter complicated parameters. These make it easy for even first-time users to use the software. In addition, by controlling pretreatment accessories, such as headspace sampling unit, the software allows continuous automatic operation, while using self-diagnostic function of the software validation assistance. If a data problem occurs, the analysis can also be automatically stopped to prevent wasting precious samples. Since measurement parameters and data analysis parameters can be controlled using a single method file and data files include instrument history information, it is capable of supporting GLP compliance and other requirements.

 

OS (Operating System)

Microsoft Windows 2000 / Windows XP / Windows Vista

 

User interface

All functions are grouped together for 'analysis' or 'postrun analysis' to facilitate easier operation. An analysis editor application allows creating and editing the method for the next analysis during the current analysis. An Assistant Bar, which varies depending on the data processing, provides easy access to frequently used functions. In addition, both of qualitative and quantitative analysis can be performed via the same window. Furthermore, the user interface takes full advantage of being a 32-bit application, such as with graphical displays, drag & drop functionality, and support for long file names. It includes many functions to help users, such as a data explorer function for managing project folders, a report editing function for creating reports using freely designed formats, a wizard function that allows specifying parameters interactively (for creating new instrument methods, batches, and quantitation compound tables, or editing retention times or reference ions), and a template function (for methods, batches, and reports) that allows performing routine analyses more efficiently.

 

On-Line Help

Pressing the [F1] key allows displaying optimized help information in any window.

A maintenance guide, called "MS NAVIGATOR," is included standard.

 

Early maintenance feedback

This feature allows immediately determining whether or not the cumulative usage count or usage hours for items in GC/MS analysis that require frequent maintenance have exceeded a pre-specified allowable range. (Applicable to septums, inserts, filaments, ion sources, detectors, rotary pumps, and rotary pump oil.) 

 

Control

GC-2010 Plus, AOC-20i and AOC-20s can be controlled as standard , while controlled AOC-5000, TurboMatrix-HS and TD-20 as option. In addition, MDGC/MS (Multi Dimensional GC/GCMS) and Twin Line MS System can be configured as option. Method creation, edition, save and execution, and continuous analysis for total system including optional units are possible.

 

Tuning

Auto-tuning is available for each ionization mode, namely EI, PCI, and NCI.

Auto-tuning can make adjustments to provide spectral patterns close to library spectra and make adjustments in a mode appropriate for inspections using special samples, such as BFB or DFTPP. Tuning results are automatically recorded in data files.

 

Data acquisition

GCMSsolution is capable to obtain data of MS and GC detectors (* any one of FID/ /FPD/FTD/TCD/ECD) simultaneously or separately.

 

Customization of batch processing

This allows using batch processing to run specified programs during continuous analysis. Analytical processes, such as pausing, stopping, and reinjecting, can be controlled by specifying batch actions.

 

GC instrument parameters

The following parameters arrangements are possible:

-       Mode switching in split/splitless/direct injection

-       Mode switching in constant linear velocity/constant column inlet pressure/constant flow

-       Programming of oven temperature/injection port/pressure/flow/purge flow

-       Mode switching in high pressure injection/normal injection

Analytical conditions and parameters used in GCsolution can be loaded into GCMSsolution in use.

 

Data display

Data acquisition window can display, in real time, chromatograms and spectra from MS, FID, or other GC detectors, graphs of the oven or injection unit temperature, or graphs of the carrier gas pressure and flowrate. TIC, MIC, or MC (SIM) chromatograms can also be displayed. Specialized Postrun sub-windows are provided respectively for MS and GC detector data. In addition to being able to display the same information as the data acquisition window, they can also compare subtracted chromatograms or compare MS spectra. Baseline and compound names, peak areas, peak heights, and other peak comments can be displayed on graphs, and the font style, size, color, and other settings can be changed as well.

 

Mass spectral data base searching

Database searching includes features such as similarity searching based on spectral similarity and filtering based on retention indices to help ensure more reliable identification of components, such as isomers. Pre-search, post-search, and reverse search features are also available. After searching, library spectra from the search results can be subtracted from the original spectrum, then the resulting spectrum can be used to search further. Index searching can also be used to search for compounds registered in libraries.

 

Integration

Peaks can be detected automatically by setting the peak slope and peak width, or by setting the maximum number of peaks and the minimum peak area/height. A time program can also be created to change the peak width, peak slope, or baseline drift value at user-specified times. Three types of smoothing can be selected – moving average, Savitzky-Golay, and bilateral. These parameters are saved separately either as qualitative processing parameters, used to detect peaks globally, or as quantitative processing parameters, used to detect specific peaks for quantitative analysis. Even when peaks are detected manually, they can be processed quickly, without requiring menu selection, by using the mouse and short-cut keys.

 

Identification

MS chromatograms and spectra from measurement data can be displayed easily to allow quickly confirming retention times or reference ion ratios. Chromatograms for quantitative analysis from reference data (MS or GC detector) can be displayed on the same screen for reference when identifying components, such as in samples with standard substances added. This helps visually to identify components more accurately. Three calculation methods are available for calculating the S/N for detected peaks – ASTM, Peak-to-Peak, and RMS. Noise intervals can be specified freely on the chromatogram as well.

 

Quantitation

Available quantitation methods include the absolute calibration curve method, internal standard method, standard addition method, area percent method, corrected area percent method, and corrected area percent method with scaling factor. Calibration curves can be created with up to 64 concentration levels specified. Using the GCMS Browser allows displaying or printing a summary list of quantitative results and statistical values for multiple sets of data or changing or recalculating calibration curves. This helps improve the efficiency of routine analyses, such as for quality control.

 

Calibration

Calibration curves can be created using up to 64 levels for each of up to 1000 compounds. Either peak area or height can be used for calibration curves and the calibration curve type can be selected from linear, broken line, quadratic, cubic, or average-coefficient approximation. It is also possible to specify whether the curve passes through the origin or not and the weighting of calibration points. Calibration curves can be created not only for individual compounds, but also by grouping multiple peaks for group calibration.

 

Creation and display of calibration curves

In addition to creating calibration curves automatically as part of batch analysis or postrun analysis, they can also be created easily by dragging data to any desired level in the calibration curve window. Also, calibration curves can be corrected by removing a calibration point from any set of data for each compound or level and directly entering coefficients for the calibration curve equation. Created calibration curves can not only be confirmed from the graph, but the peak area/height at calibration points of respective levels, response factors, the standard deviation (SD) and relative standard deviation (RSD) of multiple datasets at the same level, if available, and the contribution rate and correlation coefficient of the calibration curve are displayed. In addition, mass chromatograms (MC) are displayed for target ions and reference ions near the compound peaks being quantitated.

 

AART (Automatic Adjustment of Retention Time)

AART (Automatic Adjustment of Retention Time) function can estimate the retention times of target components from retention indices and the retention times of an alkane standard mix (C7~C33). The retention times can be corrected automatically and at once even for analysis of samples having several hundred target compounds. AART offers easy correction of retention times after capillary columns being trimmed during maintenance or exchanged with a new one from a different lot

 

Reporting

Report functions can print images of graphs just as they appear on the screen or create reports based on report format files that use a fixed format.

The following graphs can be printed as images.

・  Chromatograms and spectra

・  Comparisons of subtracted chromatograms and spectra

・  Calibration curve information

・  Library searches (search results, comparison of target and results spectra)

・  Method parameters

・  Auto-tuning results

・  Peak monitor

・  Configuration settings information

・  Batch tables

Each report format can be customized by adding report items, changing the layout, and so on. The report creation functions provide a high degree of freedom in creating reports, such as outputting data file information to headers or footers.

 

Custom report template

Report templates are also available that already include a set of report items, such as for quantitation results, calibration curves, and chromatograms, which contain functions suitable for each type of information. Report items can be customized individually, and report formats can be created by displaying the information that needs to be included in the report and freely pasting it as desired.

 

File formats

Data files are in compound structure format and include a record of the instrument configuration, method at time of measurement, tuning results at time of measurement, data processing results, and other information. In addition to importing/exporting in the AIA format, data can also be exported in ASCII, JCAMP, mzData, and mzXML formats. Quantitation results can also be output in CSV format or text format.

 

Security

User privileges can be restricted using usernames and passwords. These can be set easily by simply registering the user in a security group. Groups can be customized to allow specifying detailed security level settings for each user.

Using CLASS-Agent (optional) allows integrating the management of measurement data from other chromatography devices (such as GC or LC units) or spectroscopy devices (such as UV, FTIR, or AA spectrophotometers) and coordinating Windows and database security functions to ensure data is securely protected.

 

GLP support

GLP compliance is supported with features such as a validation statement, password protection, total system log, operation log and error log during analysis for each set of data, audit trail function, display of status log on graphs, program and data alteration check function that checks checksum and size, and a compound file structure that includes a record of all relevant information in a single file, such as data and methods.

 

[ISO9001]

GCMSsolution and GCMS-QP2010 series systems are designed and manufactured in accordance with ISO 9001 quality control standards.

 

[Physical Specification]

                            Width         Depth        Height          Weight       Power

GC                       515mm      530mm        440mm        30kg          1800VA(100V) / 2600VA(230V)

MS (Ultra)            345mm      494mm        390mm        44kg*         1000VA (RP included)

    (SE)        345mm               494mm        390mm        36kg*         1000VA (RP included)

RP                       125mm      323mm        189mm        10kg         

 

(*) PCI or PCI/NCI units add 1 kg to weight, but power requirements are unchanged.

Installation of a DI unit adds 6 kg and the additional rotary pump adds 10 kg respectively. In this case, 1000 VA of additional power is required for the additional rotary pump.

 

[Electrical characteristics]

                                   Recommended               Operating Range

(Performance guarantee)  

100V                                    +/- 5%                            +/- 10%

50 / 60 Hz                                                                +/- 0.5Hz

 

[Environmental conditions]

·        Recommended temperature range            18 to 28 ℃

(Performance guarantee)

·        Operating range                            15 to 35 ℃

·        Humidity                                        40 to 70% (Non condensing)

·        Heat value 

            Standard (EI, PCI, NCI model)            approx. 1.5kW (including GC)

            Model with DI option               approx. 1.8 kW (including GC)